Publications
The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
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Biochem Biophys Res Commun
Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes.
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Hepat Med
Comprehensive evaluation of phosphoproteomic-based kinase activity inference (preprint)
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bioRxiv
Thy‐1 restricts steatosis and liver fibrosis in steatotic liver disease
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Liver International
ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress
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Redox Biology
Lysis buffer selection guidance for mass spectrometry-based global proteomics including studies on the intersection of signal transduction and metabolism (preprint)
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bioRxiv
A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage.
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iScience
Impact of Viscosity on Human Hepatoma Spheroids in Soft Core–Shell Microcapsules
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Advanced Healthcare Materials
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
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Molecular Systems Biology
The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC Activation
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Cellular and Molecular Gastroenterology and Hepatology
Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes
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Hepatic Medicine: Evidence and Research
Extracellular Matrix Protein 1 Attenuates Hepatic Fibrosis by Inhibiting TSP-, ADAMTS-, and MMP-Mediated Latent TGF-β1 Activation
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preprint
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
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Cancer Cell International
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
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Nucleic Acids Research
FitMultiCell: simulating and parameterizing computational models of multi-scale and multi-cellular processes.
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Bioinformatics
Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging
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ChemMedChem
TGF-β1 inhibits cholesterol metabolism in hepatocytes to facilitate cell death, EMT and signals for HSC activation.
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preprint
Hepatokine‐based identification of fibrotic NASH and improved risk stratification in a multicentre cohort of NAFLD patients
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Liver International
Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study
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The Lancet
Myostatin is associated with the presence and development of acute-on-chronic liver failure
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JHEP Reports
Anti-Cancer Prodrug Cyclophosphamide Exerts Thrombogenic Effects on Human Venous Endothelial Cells Independent of CYP450 Activation—Relevance to Thrombosis
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Cells
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
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Journal of Hepatology
An integrative experimental and computational twin modeling approach to understand clonal dynamics in the normal liver
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Journal of Hepatology
Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease.
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EMBO Rep
Endoscopic Advances in Hepatology.
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Semin Liver Dis
To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure.
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Semin Liver Dis
Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease (preprint)
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bioRxiv
Hepatic inflammatory responses in liver fibrosis.
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Nat Rev Gastroenterol Hepatol
Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
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Cell Death & Disease
Sublethal necroptosis signaling promotes inflammation and liver cancer
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Immunity
Gene regulatory network inference in the era of single-cell multi-omics.
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Nat Rev Genet
Acute-On-Chronic Liver Failure: Current Interventional Treatment Options and Future Challenges.
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J Pers Med
Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH)
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Expert Opinion on Investigational Drugs
Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol Analogs
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Molecules
Isonimesulide and Its Carborane Analogues as Isoform‐Selective COX Inhibitors and Antitumor Agents
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Advanced Therapeutics
Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro
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ChemMedChem
Cholangiokines: undervalued modulators in the hepatic microenvironment
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Frontiers in Immunology
Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling
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Genes & Diseases
The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.
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Trials
Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure
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Journal of Cell Biology
Shell engineering in soft alginate‐based capsules for culturing liver spheroids
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Biotechnology Journal
Serum CXCL5 Detects Early Hepatocellular Carcinoma and Indicates Tumor Progression.
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Int J Mol Sci
FitMultiCell: Simulating and parameterizing computational models of multi-scale and multi-cellular processes
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preprint
Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors
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Molecules
Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-Matrigel matrices.
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EXCLI J
Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study
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Gut
The Multifaceted Roles of Macrophages in NAFLD Pathogenesis
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Cellular and Molecular Gastroenterology and Hepatology
Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure
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39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Repeated toxic injuries of murine liver are tolerated through minute steatosis and mild inflammation
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39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations
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Cellular and Molecular Gastroenterology and Hepatology
Hepatic C-X-C chemokine receptor type 6–expressing innate lymphocytes limit detrimental myeloid hyperactivation in acute liver injury
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Hepatology Communications
Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression
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Hepatology
Therapeutic modulation of the liver immune microenvironment
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Hepatology
The Diagnostic Approach towards Combined Hepatocellular-Cholangiocarcinoma—State of the Art and Future Perspectives
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Cancers
Monitoring TGF-β1 effects on liver cells in vivo
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39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy
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iScience
Hepatocytes reprogram liver macrophages involving control of TGF-β activation, influencing liver regeneration and injury
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Hepatology Communications
Guided interactive image segmentation using machine learning and color-based image set clustering.
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Bioinformatics
Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo.
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Cell Rep
Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines.
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Cells
Deciphering signal transduction networks in the liver by mechanistic mathematical modelling
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Biochemical Journal
Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD).
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Int J Mol Sci
Diploid hepatocytes drive physiological liver renewal in adult humans
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Cell Systems
Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21.
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Cells
Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21
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Cells
Transforming growth factor β latency: A mechanism of cytokine storage and signalling regulation in liver homeostasis and disease
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JHEP Reports
Inflammation in alcohol-associated liver disease progression
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Zeitschrift für Gastroenterologie
Liver specific, systemic and genetic contributors to alcohol-related liver disease progression
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Zeitschrift für Gastroenterologie
Cold shock protein YB-1 upregulates MDR1 transcription and thus contributes to cholangiocarcinoma chemoresistance to cisplatin
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38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber
Downregulation of ECM1 in hepatocytes as a damage response to liver injury
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38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber
MSPypeline: a python package for streamlined data analysis of mass spectrometry-based proteomics
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Bioinformatics Advances
Multi-omics profiling identifies molecular signatures of acute-on-chronic liver failure in Abcb4KO mice upon chemical intoxication
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38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber
Insulin-controlled C/EBPα expression determines the impact of TGF-β on HNF4α transcription in hepatocytes
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38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber
FOXA2 inhibits hyperbilirubinemia through maintaining apical MRP2 expression in acute liver failure
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38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber
The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis
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Hepatology Communications
Digitoxin metabolism by rat liver microsomes.
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Biochem Pharmacol