Prof. Dr. Julio Saez-Rodriguez

Pic of Prof. Dr. Julio Saez-Rodriguez

Head of Research group and Director of Institute for Computational Biomedicine – Bioquant, Heidelberg University – Faculty of Medicine, Heidelberg University Hospital, Heidelberg

Role in LiSyM-Cancer

  • Project leader in C-TIP-HCC
  • Methods to build dynamic models from large-scale functional data, esp. logic-based models, functional analysis of genomics data in pathway and network-based models
  • Mechanistic models for integrating phospho-proteomic, transcriptomic and metabolomic data with networks

Expertise

  • functional analysis of transcriptomics data: single-cell and spatial data, multi-omics integration, and understanding multi-cellular communication
  • focus is on cancer, autoimmune diseases, and conditions of the kidney and heart
  • interrogation of large biological data sets with mathematical models to unveil the molecular basis of disease as a means to develop novel therapies
  • use of existing knowledge of biological processes to support computational analysis
  • developing open-source computational tools and co-organization of the DREAM challenges

Degrees

  • 2002-2007, PhD summa cum laude in Process Engineering; Max-Planck-Institute for Dynamics of Complex Technical Systems and University of Magdeburg, Germany (Advisor: E. D. Gilles)
  • 2000-2001, Exchange Erasmus student at the University of Stuttgart, Germany
  • 1996-2001, ’Licenciatura’ (MS), in Chemical Engineering University of Oviedo, Spain, finished with the best academic record of the year

Professional Experience

  • Since 2018, Group Leader at EMBL - University Hospital Heidelberg Molecular Medicine Partnership Unit (MMPU)
  • Since 2018, Full (W3) Professor of Medical Bioinformatics and Data Analysis & Director of the Institute for Computational Biomedicine Heidelberg University, Faculty of Medicine, Germany
  • 2015-2018, Full (W3) Professor of Computational Biomedicine & Director of the Institute for Computational Biomedicine I, RWTH-Aachen University, Faculty of Medicine, Germany
  • 2015-2018, Visiting group leader at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI)
  • 2010-2015, Group Leader at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI), with a joint appointment in the EMBL Genome Biology Unit in Heidelberg
  • 2010-2015, Senior fellow at Wolfson College (Cambridge, UK)
  • 2008-2010, Scientific Coordinator of the NIH-NIGMS Cell Decision Process Center, Cambridge, MA, USA
  • 2007-2010, Postdoctoral Fellow, Harvard Medical School and MIT, Boston USA
  • 2002-2007, Research Assistant, Max Planck Institute, Magdeburg, Germany
  • 2001-2002, Research assistant, University of Stuttgart, Institute of Biochemical Engineering, Germany, and Insilico Biotechnology, Germany