Prof. Dr. Jan Hengstler

Pic of Prof. Dr. Jan Hengstler

Head of Research Group – System Toxicology – Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund

Role in LiSyM-Cancer

  • Project leader in C-TIP-HCC
  • Mouse model for hepatocyte transformation from necroptosis
  • Morphological profiling and in vivo live cell intravital imaging
  • Reporter mice for in vivo imaging of DAMP release using the two-photon toolbox

Expertise

  • Liver physiology, functional liver imaging and hepatotoxicity
  • Functional imaging techniques based on two-photon microscopy, photoactivation, raster image correlation spectroscopy and MALDI-MSI for the analysis of intact tissues in living organisms
  • Hepatocyte in vitro systems, including 3D culture techniques and organoids

Degrees

  • 1998, Habilitation in Pharmacology and Toxicology, Faculty of Medicine, University of Mainz, Germany
  • 1997, Physician specialized in Pharmacology and Toxicology
  • 1992, License to practice medicine (Approbation)
  • 1991, Thesis (MD): DNA damage in patients treated with alkylating agents Faculty of Medicine, University of Mainz, Germany
  • 1984-1990, Study of Medicine, Faculty of Medicine, University of Mainz, Germany

Professional Experience

  • Since 2007, W3 Full Professor and Scientific Director, Department of Toxicolgy, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund Technical University, Germany
  • 2003-2007, Professor of Molecular Pharmacology and Toxicology, Department of Pharmacology, Faculty of Medicine, University of Leipzig, Germany
  • 2006-2007, Provisional head of the Institute of Forensic Medicine and Forensic Toxicology, Department of Forensic Medicine, Faculty of Medicine, University of Leipzig, Germany
  • 1990-2002 Research scientist at the Institute of Toxicology, Faculty of Medicine, University of Mainz, Germany

Honors and Awards (selection)

  • 2017-2019 Clarivate, highly cited researcher in the category Pharmacology and Toxicology
  • 2016, Ebert Prize of the American Pharmacists Association
  • 2009, Bo-Holmstedt Memorial Lecture of the EUROTOX
  • 2002, Aventis-Award 2002
  • 2001, Rudolf Buchheim Award of the German Society of Pharmacology and Toxicology (DGPT)
  • 1999, Innovation Award of Rhineland Palatinate, Germany